About Heat shock 70 kDa protein 4L
Heat shock 70 kDa protein 4L (HSPA4L) is a protein
from Homo sapiens identified by UniProt accession
O95757, 839 residues long.
MolForge cross-references it against 0 known binders and
97 disease associations.
Target properties
| Protein name | Heat shock 70 kDa protein 4L |
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| UniProt accession | O95757 |
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| Gene | HSPA4L |
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| Organism | Homo sapiens |
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| Length | 839 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (97)
Diseases linked to this target (Open Targets).
- IGF-1 measurement · score 0.23
- platelet count · score 0.22
- mean corpuscular volume · score 0.19
- vital capacity · score 0.16
- mean corpuscular hemoglobin · score 0.12
- erythrocyte count · score 0.08
- reticulocyte measurement · score 0.08
- creatinine measurement · score 0.07
- red blood cell density measurement · score 0.07
- mean corpuscular hemoglobin concentration · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O95757-F1 | alphafold | PREDICTED | 86.08 | — |
Amino-acid sequence (839 residues)
MSVVGIDLGF LNCYIAVARS GGIETIANEY SDRCTPACIS LGSRTRAIGN AAKSQIVTNV RNTIHGFKKL HGRSFDDPIV QTERIRLPYE LQKMPNGSAG VKVRYLEEER PFAIEQVTGM LLAKLKETSE NALKKPVADC VISIPSFFTD AERRSVMAAA QVAGLNCLRL MNETTAVALA YGIYKQDLPP LDEKPRNVVF IDMGHSAYQV LVCAFNKGKL KVLATTFDPY LGGRNFDEAL VDYFCDEFKT KYKINVKENS RALLRLYQEC EKLKKLMSAN ASDLPLNIEC FMNDLDVSSK MNRAQFEQLC ASLLARVEPP LKAVMEQANL QREDISSIEI VGGATRIPAV KEQITKFFLK DISTTLNADE AVARGCALQC AILSPAFKVR EFSITDLVPY SITLRWKTSF EDGSGECEVF CKNHPAPFSK VITFHKKEPF ELEAFYTNLH EVPYPDARIG SFTIQNVFPQ SDGDSSKVKV KVRVNIHGIF SVASASVIEK QNLEGDHSDA PMETETSFKN ENKDNMDKMQ VDQEEGHQKC HAEHTPEEEI DHTGAKTKSA VSDKQDRLNQ TLKKGKVKSI DLPIQSSLCR QLGQDLLNSY IENEGKMIMQ DKLEKERNDA KNAVEEYVYD FRDRLGTVYE KFITPEDLSK LSAVLEDTEN WLYEDGEDQP KQVYVDKLQE LKKYGQPIQM KYMEHEERPK ALNDLGKKIQ LVMKVIEAYR NKDERYDHLD PTEMEKVEKC ISDAMSWLNS KMNAQNKLSL TQDPVVKVSE IVAKSKELDN FCNPIIYKPK PKAEVPEDKP KANSEHNGPM DGQSGTETKS DSTKDSSQHT KSSGEMEVD
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