Polypyrimidine tract-binding protein 3 (PTBP3)

About Polypyrimidine tract-binding protein 3

Polypyrimidine tract-binding protein 3 (PTBP3) is a protein from Homo sapiens identified by UniProt accession O95758, 552 residues long. MolForge cross-references it against 0 known binders and 65 disease associations.

Target properties

Protein name	Polypyrimidine tract-binding protein 3
UniProt accession	O95758
Gene	PTBP3
Organism	Homo sapiens
Length	552 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (65)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.28
monocyte count · score 0.27
body weight · score 0.27
reticulocyte count · score 0.24
diet measurement · score 0.17
neoplasm · score 0.11
body height · score 0.10
erythrocyte count · score 0.08
hepatocellular carcinoma · score 0.08
glioblastoma multiforme · score 0.08

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O95758-F1	alphafold	PREDICTED	69.20	—

Amino-acid sequence (552 residues)

MDGVVTDLIT VGLKRGSDEL LSSGIINGPF TMNSSTPSTA NGNDSKKFKR DRPPCSPSRV LHLRKIPCDV TEAEIISLGL PFGKVTNLLM LKGKSQAFLE MASEEAAVTM VNYYTPITPH LRSQPVYIQY SNHRELKTDN LPNQARAQAA LQAVSAVQSG SLALSGGPSN EGTVLPGQSP VLRIIIENLF YPVTLEVLHQ IFSKFGTVLK IITFTKNNQF QALLQYADPV NAHYAKMALD GQNIYNACCT LRIDFSKLTS LNVKYNNDKS RDFTRLDLPT GDGQPSLEPP MAAAFGAPGI ISSPYAGAAG FAPAIGFPQA TGLSVPAVPG ALGPLTITSS AVTGRMAIPG ASGIPGNSVL LVTNLNPDLI TPHGLFILFG VYGDVHRVKI MFNKKENALV QMADANQAQL AMNHLSGQRL YGKVLRATLS KHQAVQLPRE GQEDQGLTKD FSNSPLHRFK KPGSKNFQNI FPPSATLHLS NIPPSVTVDD LKNLFIEAGC SVKAFKFFQK DRKMALIQLG SVEEAIQALI ELHNHDLGEN HHLRVSFSKS TI

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards