TBC1 domain family member 8 (TBC1D8)

About TBC1 domain family member 8

TBC1 domain family member 8 (TBC1D8) is a protein from Homo sapiens identified by UniProt accession O95759, 1140 residues long. MolForge cross-references it against 0 known binders and 179 disease associations.

Target properties

Protein name	TBC1 domain family member 8
UniProt accession	O95759
Gene	TBC1D8
Organism	Homo sapiens
Length	1140 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (179)

Diseases linked to this target (Open Targets).

neutrophil count · score 0.45
leukocyte count · score 0.43
myeloid white cell count · score 0.42
reticulocyte count · score 0.35
reticulocyte measurement · score 0.35
lymphocyte percentage of leukocytes · score 0.34
neutrophil percentage of leukocytes · score 0.34
smoking status measurement · score 0.31
carotid artery intima media thickness · score 0.31
creatinine measurement · score 0.29

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O95759-F1	alphafold	PREDICTED	78.46	—

Amino-acid sequence (1140 residues)

MWLKPEEVLL KNALKLWVTQ KSSCYFILQR RRGHGEGGGR LTGRLVGALD AVLDSNARVA PFRILLQVPG SQVYSPIACG ATLEEINQHW DWLEQNLLHT LSVFDNKDDI ASFVKGKVKA LIAEETSSRL AEQEEEPEKF REALVKFEAR FNFPEAEKLV TYYSCCCWKG RVPRQGWLYL SINHLCFYSF FLGKELKLVV PWVDIQKLER TSNVFLTDTI RITTQNKERD FSMFLNLDEV FKVMEQLADV TLRRLLDNEV FDLDPDLQEP SQITKRDLEA RAQNEFFRAF FRLPRKEKLH AVVDCSLWTP FSRCHTTGRM FASDSYICFA SREDGCCKII LPLREVVSIE KMEDTSLLPH PIIVSIRSKV AFQFIELRDR DSLVEALLAR LKQVHANHPV HYDTSADDDM ASLVFHSTSM CSDHRFGDLE MMSSQNSEES EKEKSPLMHP DALVTAFQQS GSQSPDSRMS REQIKISLWN DHFVEYGRTV CMFRTEKIRK LVAMGIPESL RGRLWLLFSD AVTDLASHPG YYGNLVEESL GKCCLVTEEI ERDLHRSLPE HPAFQNETGI AALRRVLTAY AHRNPKIGYC QSMNILTSVL LLYTKEEEAF WLLVAVCERM LPDYFNHRVI GAQVDQSVFE ELIKGHLPEL AEHMNDLSAL ASVSLSWFLT LFLSIMPLES AVNVVDCFFY DGIKAIFQLG LAVLEANAED LCSSKDDGQA LMILSRFLDH IKNEDSPGPP VGSHHAFFSD DQEPYPVTDI SDLIRDSYEK FGDQSVEQIE HLRYKHRIRV LQGHEDTTKQ NVLRVVIPEV SILPEDLEEL YDLFKREHMM SCYWEQPRPM ASRHDPSRPY AEQYRIDARQ FAHLFQLVSP WTCGAHTEIL AERTFRLLDD NMDQLIEFKA FVSCLDIMYN GEMNEKIKLL YRLHIPPALT ENDRDSQSPL RNPLLSTSRP LVFGKPNGDA VDYQKQLKQM IKDLAKEKDK TEKELPKMSQ REFIQFCKTL YSMFHEDPEE NDLYQAIATV TTLLLQIGEV GQRGSSSGSC SQECGEELRA SAPSPEDSVF ADTGKTPQDS QAFPEAAERD WTVSLEHILA SLLTEQSLVN FFEKPLDMKS KLENAKINQY NLKTFEMSHQ SQSELKLSNL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards