About Interleukin-33
Interleukin-33 (IL33) is a protein
from Homo sapiens identified by UniProt accession
O95760, 270 residues long.
MolForge cross-references it against 0 known binders and
1,119 disease associations.
Target properties
| Protein name | Interleukin-33 |
|---|
| UniProt accession | O95760 |
|---|
| Gene | IL33 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 270 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (1119)
Diseases linked to this target (Open Targets).
- eosinophil count · score 0.66
- eosinophil percentage of leukocytes · score 0.63
- asthma · score 0.62
- allergic disease · score 0.57
- childhood onset asthma · score 0.55
- allergic rhinitis · score 0.46
- seasonal allergic rhinitis · score 0.45
- drug use measurement · score 0.43
- chronic obstructive pulmonary disease · score 0.39
- respiratory system disease · score 0.38
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O95760-F1 | alphafold | PREDICTED | 66.37 | — |
Amino-acid sequence (270 residues)
MKPKMKYSTN KISTAKWKNT ASKALCFKLG KSQQKAKEVC PMYFMKLRSG LMIKKEACYF RRETTKRPSL KTGRKHKRHL VLAACQQQST VECFAFGISG VQKYTRALHD SSITGISPIT EYLASLSTYN DQSITFALED ESYEIYVEDL KKDEKKDKVL LSYYESQHPS NESGDGVDGK MLMVTLSPTK DFWLHANNKE HSVELHKCEK PLPDQAFFVL HNMHSNCVSF ECKTDPGVFI GVKDNHLALI KVDSSENLCT ENILFKLSET
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