Antiviral innate immune response receptor RIG-I (RIGI)

About Antiviral innate immune response receptor RIG-I

Antiviral innate immune response receptor RIG-I (RIGI) is a protein from Homo sapiens identified by UniProt accession O95786, 925 residues long. MolForge cross-references it against 0 known binders and 543 disease associations.

Target properties

Protein name	Antiviral innate immune response receptor RIG-I
UniProt accession	O95786
Gene	RIGI
Organism	Homo sapiens
Length	925 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (543)

Diseases linked to this target (Open Targets).

Singleton-Merten dysplasia · score 0.56
psoriasis · score 0.46
hemoglobin measurement · score 0.45
hematocrit · score 0.43
red blood cell density measurement · score 0.40
neuroticism measurement · score 0.40
erythrocyte count · score 0.39
COVID-19 · score 0.38
type 2 diabetes mellitus · score 0.30
genetic disorder · score 0.19

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O95786-F1	alphafold	PREDICTED	85.17	—

Amino-acid sequence (925 residues)

MTTEQRRSLQ AFQDYIRKTL DPTYILSYMA PWFREEEVQY IQAEKNNKGP MEAATLFLKF LLELQEEGWF RGFLDALDHA GYSGLYEAIE SWDFKKIEKL EEYRLLLKRL QPEFKTRIIP TDIISDLSEC LINQECEEIL QICSTKGMMA GAEKLVECLL RSDKENWPKT LKLALEKERN KFSELWIVEK GIKDVETEDL EDKMETSDIQ IFYQEDPECQ NLSENSCPPS EVSDTNLYSP FKPRNYQLEL ALPAMKGKNT IICAPTGCGK TFVSLLICEH HLKKFPQGQK GKVVFFANQI PVYEQQKSVF SKYFERHGYR VTGISGATAE NVPVEQIVEN NDIIILTPQI LVNNLKKGTI PSLSIFTLMI FDECHNTSKQ HPYNMIMFNY LDQKLGGSSG PLPQVIGLTA SVGVGDAKNT DEALDYICKL CASLDASVIA TVKHNLEELE QVVYKPQKFF RKVESRISDK FKYIIAQLMR DTESLAKRIC KDLENLSQIQ NREFGTQKYE QWIVTVQKAC MVFQMPDKDE ESRICKALFL YTSHLRKYND ALIISEHARM KDALDYLKDF FSNVRAAGFD EIEQDLTQRF EEKLQELESV SRDPSNENPK LEDLCFILQE EYHLNPETIT ILFVKTRALV DALKNWIEGN PKLSFLKPGI LTGRGKTNQN TGMTLPAQKC ILDAFKASGD HNILIATSVA DEGIDIAQCN LVILYEYVGN VIKMIQTRGR GRARGSKCFL LTSNAGVIEK EQINMYKEKM MNDSILRLQT WDEAVFREKI LHIQTHEKFI RDSQEKPKPV PDKENKKLLC RKCKALACYT ADVRVIEECH YTVLGDAFKE CFVSRPHPKP KQFSSFEKRA KIFCARQNCS HDWGIHVKYK TFEIPVIKIE SFVVEDIATG VQTLYSKWKD FHFEKIPFDP AEMSK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards