About Probable G-protein coupled receptor 75
Probable G-protein coupled receptor 75 (GPR75) is a protein
from Homo sapiens identified by UniProt accession
O95800, 540 residues long.
MolForge cross-references it against 0 known binders and
49 disease associations.
Target properties
| Protein name | Probable G-protein coupled receptor 75 |
|---|
| UniProt accession | O95800 |
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| Gene | GPR75 |
|---|
| Organism | Homo sapiens |
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| Length | 540 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (49)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.45
- diet measurement · score 0.09
- hemoglobin measurement · score 0.08
- hematocrit · score 0.08
- body mass index · score 0.08
- anorexia nervosa · score 0.06
- neutrophil percentage of leukocytes · score 0.05
- lymphocyte count · score 0.05
- lymphocyte percentage of leukocytes · score 0.05
- age at first sexual intercourse measurement · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O95800-F1 | alphafold | PREDICTED | 63.95 | — |
Amino-acid sequence (540 residues)
MNSTGHLQDA PNATSLHVPH SQEGNSTSLQ EGLQDLIHTA TLVTCTFLLA VIFCLGSYGN FIVFLSFFDP AFRKFRTNFD FMILNLSFCD LFICGVTAPM FTFVLFFSSA SSIPDAFCFT FHLTSSGFII MSLKTVAVIA LHRLRMVLGK QPNRTASFPC TVLLTLLLWA TSFTLATLAT LKTSKSHLCL PMSSLIAGKG KAILSLYVVD FTFCVAVVSV SYIMIAQTLR KNAQVRKCPP VITVDASRPQ PFMGVPVQGG GDPIQCAMPA LYRNQNYNKL QHVQTRGYTK SPNQLVTPAA SRLQLVSAIN LSTAKDSKAV VTCVIIVLSV LVCCLPLGIS LVQVVLSSNG SFILYQFELF GFTLIFFKSG LNPFIYSRNS AGLRRKVLWC LQYIGLGFFC CKQKTRLRAM GKGNLEVNRN KSSHHETNSA YMLSPKPQKK FVDQACGPSH SKESMVSPKI SAGHQHCGQS SSTPINTRIE PYYSIYNSSP SQEESSPCNL QPVNSFGFAN SYIAMHYHTT NDLVQEYDST SAKQIPVPSV
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