Hsp70/Hsp90 co-chaperone CNS1 homolog (TTC4)

About Hsp70/Hsp90 co-chaperone CNS1 homolog

Hsp70/Hsp90 co-chaperone CNS1 homolog (TTC4) is a protein from Homo sapiens identified by UniProt accession O95801, 387 residues long. MolForge cross-references it against 0 known binders and 23 disease associations.

Target properties

Protein name	Hsp70/Hsp90 co-chaperone CNS1 homolog
UniProt accession	O95801
Gene	TTC4
Organism	Homo sapiens
Length	387 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (23)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.53
benign connective and soft tissue neoplasm · score 0.09
blood protein measurement · score 0.03
metabolite measurement · score 0.03
neoplasm · score 0.02
Sepsis · score 0.02
Rheumatoid arthritis · score 0.01
melanoma · score 0.01
infection · score 0.01
infect · score 0.01

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O95801-F1	alphafold	PREDICTED	86.88	—

Amino-acid sequence (387 residues)

MEQPGQDPTS DDVMDSFLEK FQSQPYRGGF HEDQWEKEFE KVPLFMSRAP SEIDPRENPD LACLQSIIFD EERSPEEQAK TYKDEGNDYF KEKDYKKAVI SYTEGLKKKC ADPDLNAVLY TNRAAAQYYL GNFRSALNDV TAARKLKPCH LKAIIRGALC HLELKHFAEA VNWCDEGLQI DAKEKKLLEM RAKADKLKRI EQRDVRKANL KEKKERNQNE ALLQAIKARN IRLSEAACED EDSASEGLGE LFLDGLSTEN PHGARLSLDG QGRLSWPVLF LYPEYAQSDF ISAFHEDSRF IDHLMVMFGE TPSWDLEQKY CPDNLEVYFE DEDRAELYRV PAKSTLLQVL QHQRYFVKAL TPAFLVCVGS SPFCKNFLRG RKVYQIR

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards