About BAG family molecular chaperone regulator 2
BAG family molecular chaperone regulator 2 (BAG2) is a protein
from Homo sapiens identified by UniProt accession
O95816, 211 residues long.
MolForge cross-references it against 0 known binders and
88 disease associations.
Target properties
| Protein name | BAG family molecular chaperone regulator 2 |
|---|
| UniProt accession | O95816 |
|---|
| Gene | BAG2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 211 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (88)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.33
- Carpenter syndrome · score 0.19
- RAB23-related Carpenter syndrome · score 0.19
- neoplasm · score 0.10
- hepatocellular carcinoma · score 0.09
- esophageal squamous cell carcinoma · score 0.08
- coronary artery disease · score 0.06
- MODY · score 0.05
- cancer · score 0.05
- acute lymphoblastic leukemia · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O95816-F1 | alphafold | PREDICTED | 86.22 | — |
Amino-acid sequence (211 residues)
MAQAKINAKA NEGRFCRSSS MADRSSRLLE SLDQLELRVE ALREAATAVE QEKEILLEMI HSIQNSQDMR QISDGEREEL NLTANRLMGR TLTVEVSVET IRNPQQQESL KHATRIIDEV VNKFLDDLGN AKSHLMSLYS ACSSEVPHGP VDQKFQSIVI GCALEDQKKI KRRLETLLRN IENSDKAIKL LEHSKGAGSK TLQQNAESRF N
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