About BAG family molecular chaperone regulator 3
BAG family molecular chaperone regulator 3 (BAG3) is a protein
from Homo sapiens identified by UniProt accession
O95817, 575 residues long.
MolForge cross-references it against 0 known binders and
324 disease associations.
Target properties
| Protein name | BAG family molecular chaperone regulator 3 |
|---|
| UniProt accession | O95817 |
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| Gene | BAG3 |
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| Organism | Homo sapiens |
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| Length | 575 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
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Disease associations (324)
Diseases linked to this target (Open Targets).
- dilated cardiomyopathy 1HH · score 0.79
- myofibrillar myopathy 6 · score 0.78
- dilated cardiomyopathy · score 0.69
- Abnormality of the cardiovascular system · score 0.55
- myofibrillar myopathy · score 0.48
- Dilated cardiomyopathy · score 0.47
- familial dilated cardiomyopathy · score 0.45
- electrocardiography · score 0.42
- hypertrophic cardiomyopathy · score 0.42
- myocarditis · score 0.41
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O95817-F1 | alphafold | PREDICTED | 57.24 | — |
Amino-acid sequence (575 residues)
MSAATHSPMM QVASGNGDRD PLPPGWEIKI DPQTGWPFFV DHNSRTTTWN DPRVPSEGPK ETPSSANGPS REGSRLPPAR EGHPVYPQLR PGYIPIPVLH EGAENRQVHP FHVYPQPGMQ RFRTEAAAAA PQRSQSPLRG MPETTQPDKQ CGQVAAAAAA QPPASHGPER SQSPAASDCS SSSSSASLPS SGRSSLGSHQ LPRGYISIPV IHEQNVTRPA AQPSFHQAQK THYPAQQGEY QTHQPVYHKI QGDDWEPRPL RAASPFRSSV QGASSREGSP ARSSTPLHSP SPIRVHTVVD RPQQPMTHRE TAPVSQPENK PESKPGPVGP ELPPGHIPIQ VIRKEVDSKP VSQKPPPPSE KVEVKVPPAP VPCPPPSPGP SAVPSSPKSV ATEERAAPST APAEATPPKP GEAEAPPKHP GVLKVEAILE KVQGLEQAVD NFEGKKTDKK YLMIEEYLTK ELLALDSVDP EGRADVRQAR RDGVRKVQTI LEKLEQKAID VPGQVQVYEL QPSNLEADQP LQAIMEMGAV AADKGKKNAG NAEDPHTETQ QPEATAAATS NPSSMTDTPG NPAAP
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