About Malonyl-CoA decarboxylase, mitochondrial
Malonyl-CoA decarboxylase, mitochondrial (MLYCD) is a protein
from Homo sapiens identified by UniProt accession
O95822, 493 residues long.
MolForge cross-references it against 0 known binders and
68 disease associations.
Target properties
| Protein name | Malonyl-CoA decarboxylase, mitochondrial |
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| UniProt accession | O95822 |
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| Gene | MLYCD |
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| Organism | Homo sapiens |
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| Length | 493 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (68)
Diseases linked to this target (Open Targets).
- malonic aciduria · score 0.81
- hypertrophic cardiomyopathy · score 0.37
- Intellectual disability · score 0.26
- sleep measurement · score 0.26
- genetic disorder · score 0.19
- adolescent idiopathic scoliosis · score 0.17
- low density lipoprotein cholesterol measurement · score 0.12
- sex hormone-binding globulin measurement · score 0.11
- alkaline phosphatase measurement · score 0.11
- serum alanine aminotransferase measurement · score 0.11
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O95822-F1 | alphafold | PREDICTED | 89.92 | — |
Amino-acid sequence (493 residues)
MRGFGPGLTA RRLLPLRLPP RPPGPRLASG QAAGALERAM DELLRRAVPP TPAYELREKT PAPAEGQCAD FVSFYGGLAE TAQRAELLGR LARGFGVDHG QVAEQSAGVL HLRQQQREAA VLLQAEDRLR YALVPRYRGL FHHISKLDGG VRFLVQLRAD LLEAQALKLV EGPDVREMNG VLKGMLSEWF SSGFLNLERV TWHSPCEVLQ KISEAEAVHP VKNWMDMKRR VGPYRRCYFF SHCSTPGEPL VVLHVALTGD ISSNIQAIVK EHPPSETEEK NKITAAIFYS ISLTQQGLQG VELGTFLIKR VVKELQREFP HLGVFSSLSP IPGFTKWLLG LLNSQTKEHG RNELFTDSEC KEISEITGGP INETLKLLLS SSEWVQSEKL VRALQTPLMR LCAWYLYGEK HRGYALNPVA NFHLQNGAVL WRINWMADVS LRGITGSCGL MANYRYFLEE TGPNSTSYLG SKIIKASEQV LSLVAQFQKN SKL
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