About Ferry endosomal RAB5 effector complex subunit 4
Ferry endosomal RAB5 effector complex subunit 4 (CRYZL1) is a protein
from Homo sapiens identified by UniProt accession
O95825, 349 residues long.
MolForge cross-references it against 0 known binders and
30 disease associations.
Target properties
| Protein name | Ferry endosomal RAB5 effector complex subunit 4 |
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| UniProt accession | O95825 |
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| Gene | CRYZL1 |
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| Organism | Homo sapiens |
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| Length | 349 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (30)
Diseases linked to this target (Open Targets).
- body height · score 0.16
- mean corpuscular volume · score 0.11
- Red cell distribution width · score 0.10
- erythrocyte count · score 0.09
- mean corpuscular hemoglobin · score 0.09
- mean corpuscular hemoglobin concentration · score 0.09
- attention deficit hyperactivity disorder · score 0.09
- red blood cell density measurement · score 0.08
- schizophrenia 15 · score 0.07
- attention deficit-hyperactivity disorder 8 · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O95825-F1 | alphafold | PREDICTED | 91.77 | — |
Amino-acid sequence (349 residues)
MKGLYFQQSS TDEEITFVFQ EKEDLPVTED NFVKLQVKAC ALSQINTKLL AEMKMKKDLF PVGREIAGIV LDVGSKVSFF QPDDEVVGIL PLDSEDPGLC EVVRVHEHYL VHKPEKVTWT EAAGSIRDGV RAYTALHYLS HLSPGKSVLI MDGASAFGTI AIQLAHHRGA KVISTACSLE DKQCLERFRP PIARVIDVSN GKVHVAESCL EETGGLGVDI VLDAGVRLYS KDDEPAVKLQ LLPHKHDIIT LLGVGGHWVT TEENLQLDPP DSHCLFLKGA TLAFLNDEVW NLSNVQQGKY LCILKDVMEK LSTGVFRPQL DEPIPLYEAK VSMEAVQKNQ GRKKQVVQF
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