About Apoptosis-inducing factor 1, mitochondrial
Apoptosis-inducing factor 1, mitochondrial (AIFM1) is a protein
from Homo sapiens identified by UniProt accession
O95831, 613 residues long.
MolForge cross-references it against 0 known binders and
325 disease associations.
Target properties
| Protein name | Apoptosis-inducing factor 1, mitochondrial |
|---|
| UniProt accession | O95831 |
|---|
| Gene | AIFM1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 613 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (325)
Diseases linked to this target (Open Targets).
- severe X-linked mitochondrial encephalomyopathy · score 0.81
- X-linked hereditary sensory and autonomic neuropathy with deafness · score 0.78
- X-linked Charcot-Marie-Tooth disease type 4 · score 0.75
- spondyloepimetaphyseal dysplasia, Bieganski type · score 0.74
- Charcot-Marie-Tooth disease X-linked recessive 4 · score 0.73
- X-linked hereditary sensory and autonomic neuropathy with hearing loss · score 0.66
- neurodegenerative disease · score 0.53
- Charcot-Marie-Tooth disease · score 0.52
- combined oxidative phosphorylation deficiency · score 0.52
- auditory neuropathy · score 0.49
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O95831-F1 | alphafold | PREDICTED | 85.81 | — |
Amino-acid sequence (613 residues)
MFRCGGLAAG ALKQKLVPLV RTVCVRSPRQ RNRLPGNLFQ RWHVPLELQM TRQMASSGAS GGKIDNSVLV LIVGLSTVGA GAYAYKTMKE DEKRYNERIS GLGLTPEQKQ KKAALSASEG EEVPQDKAPS HVPFLLIGGG TAAFAAARSI RARDPGARVL IVSEDPELPY MRPPLSKELW FSDDPNVTKT LRFKQWNGKE RSIYFQPPSF YVSAQDLPHI ENGGVAVLTG KKVVQLDVRD NMVKLNDGSQ ITYEKCLIAT GGTPRSLSAI DRAGAEVKSR TTLFRKIGDF RSLEKISREV KSITIIGGGF LGSELACALG RKARALGTEV IQLFPEKGNM GKILPEYLSN WTMEKVRREG VKVMPNAIVQ SVGVSSGKLL IKLKDGRKVE TDHIVAAVGL EPNVELAKTG GLEIDSDFGG FRVNAELQAR SNIWVAGDAA CFYDIKLGRR RVEHHDHAVV SGRLAGENMT GAAKPYWHQS MFWSDLGPDV GYEAIGLVDS SLPTVGVFAK ATAQDNPKSA TEQSGTGIRS ESETESEASE ITIPPSTPAV PQAPVQGEDY GKGVIFYLRD KVVVGIVLWN IFNRMPIARK IIKDGEQHED LNEVAKLFNI HED
Explore Apoptosis-inducing factor 1, mitochondrial with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets