About Echinoderm microtubule-associated protein-like 2
Echinoderm microtubule-associated protein-like 2 (EML2) is a protein
from Homo sapiens identified by UniProt accession
O95834, 649 residues long.
MolForge cross-references it against 0 known binders and
33 disease associations.
Target properties
| Protein name | Echinoderm microtubule-associated protein-like 2 |
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| UniProt accession | O95834 |
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| Gene | EML2 |
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| Organism | Homo sapiens |
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| Length | 649 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (33)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.44
- type 2 diabetes mellitus · score 0.25
- emotional symptom measurement · score 0.21
- Drugs used in diabetes use measurement · score 0.19
- diabetes mellitus · score 0.18
- cortical thickness · score 0.18
- HbA1c measurement · score 0.14
- serum alanine aminotransferase measurement · score 0.11
- hemoglobin A1 measurement · score 0.10
- hemoglobin D disease · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O95834-F1 | alphafold | PREDICTED | 95.59 | — |
Amino-acid sequence (649 residues)
MSSFGAGKTK EVIFSVEDGS VKMFLRGRPV PMMIPDELAP TYSLDTRSEL PSCRLKLEWV YGYRGRDCRA NLYLLPTGEI VYFVASVAVL YSVEEQRQRH YLGHNDDIKC LAIHPDMVTI ATGQVAGTTK EGKPLPPHVR IWDSVSLSTL HVLGLGVFDR AVCCVGFSKS NGGNLLCAVD ESNDHMLSVW DWAKETKVVD VKCSNEAVLV ATFHPTDPTV LITCGKSHIY FWTLEGGSLS KRQGLFEKHE KPKYVLCVTF LEGGDVVTGD SGGNLYVWGK GGNRITQAVL GAHDGGVFGL CALRDGTLVS GGGRDRRVVL WGSDYSKLQE VEVPEDFGPV RTVAEGHGDT LYVGTTRNSI LQGSVHTGFS LLVQGHVEEL WGLATHPSRA QFVTCGQDKL VHLWSSDSHQ PLWSRIIEDP ARSAGFHPSG SVLAVGTVTG RWLLLDTETH DLVAIHTDGN EQISVVSFSP DGAYLAVGSH DNLVYVYTVD QGGRKVSRLG KCSGHSSFIT HLDWAQDSSC FVTNSGDYEI LYWDPATCKQ ITSADAVRNM EWATATCVLG FGVFGIWSEG ADGTDINAVA RSHDGKLLAS ADDFGKVHLF SYPCCQPRAL SHKYGGHSSH VTNVAFLWDD SMALTTGGKD TSVLQWRVV
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