About Glucagon-like peptide 2 receptor
Glucagon-like peptide 2 receptor (GLP2R) is a protein
from Homo sapiens identified by UniProt accession
O95838, 553 residues long.
MolForge cross-references it against 0 known binders and
89 disease associations.
Target properties
| Protein name | Glucagon-like peptide 2 receptor |
|---|
| UniProt accession | O95838 |
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| Gene | GLP2R |
|---|
| Organism | Homo sapiens |
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| Length | 553 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (89)
Diseases linked to this target (Open Targets).
- short bowel syndrome · score 0.55
- malabsorption syndrome · score 0.37
- primary short bowel syndrome · score 0.37
- type 2 diabetes mellitus · score 0.33
- HbA1c measurement · score 0.24
- protein measurement · score 0.24
- hemoglobin A1 measurement · score 0.23
- glucose-dependent insulinotropic peptide measurement · score 0.23
- glucose tolerance test · score 0.23
- ferritin measurement · score 0.23
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O95838-F1 | alphafold | PREDICTED | 73.46 | — |
Amino-acid sequence (553 residues)
MKLGSSRAGP GRGSAGLLPG VHELPMGIPA PWGTSPLSFH RKCSLWAPGR PFLTLVLLVS IKQVTGSLLE ETTRKWAQYK QACLRDLLKE PSGIFCNGTF DQYVCWPHSS PGNVSVPCPS YLPWWSEESS GRAYRHCLAQ GTWQTIENAT DIWQDDSECS ENHSFKQNVD RYALLSTLQL MYTVGYSFSL ISLFLALTLL LFLRKLHCTR NYIHMNLFAS FILRTLAVLV KDVVFYNSYS KRPDNENGWM SYLSEMSTSC RSVQVLLHYF VGANYLWLLV EGLYLHTLLE PTVLPERRLW PRYLLLGWAF PVLFVVPWGF ARAHLENTGC WTTNGNKKIW WIIRGPMMLC VTVNFFIFLK ILKLLISKLK AHQMCFRDYK YRLAKSTLVL IPLLGVHEIL FSFITDDQVE GFAKLIRLFI QLTLSSFHGF LVALQYGFAN GEVKAELRKY WVRFLLARHS GCRACVLGKD FRFLGKCPKK LSEGDGAEKL RKLQPSLNSG RLLHLAMRGL GELGAQPQQD HARWPRGSSL SECSEGDVTM ANTMEEILEE SEI
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