Angiopoietin-related protein 1 (ANGPTL1)

About Angiopoietin-related protein 1

Angiopoietin-related protein 1 (ANGPTL1) is a protein from Homo sapiens identified by UniProt accession O95841, 491 residues long. MolForge cross-references it against 0 known binders and 136 disease associations.

Target properties

Protein name	Angiopoietin-related protein 1
UniProt accession	O95841
Gene	ANGPTL1
Organism	Homo sapiens
Length	491 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (136)

Diseases linked to this target (Open Targets).

vital capacity · score 0.29
cortical surface area measurement · score 0.25
blood protein measurement · score 0.25
cortical thickness · score 0.25
brain measurement · score 0.25
forced expiratory volume · score 0.23
grip strength measurement · score 0.21
neuroimaging measurement · score 0.20
pulse pressure measurement · score 0.17
body height · score 0.10

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O95841-F1	alphafold	PREDICTED	77.65	—

Amino-acid sequence (491 residues)

MKTFTWTLGV LFFLLVDTGH CRGGQFKIKK INQRRYPRAT DGKEEAKKCA YTFLVPEQRI TGPICVNTKG QDASTIKDMI TRMDLENLKD VLSRQKREID VLQLVVDVDG NIVNEVKLLR KESRNMNSRV TQLYMQLLHE IIRKRDNSLE LSQLENKILN VTTEMLKMAT RYRELEVKYA SLTDLVNNQS VMITLLEEQC LRIFSRQDTH VSPPLVQVVP QHIPNSQQYT PGLLGGNEIQ RDPGYPRDLM PPPDLATSPT KSPFKIPPVT FINEGPFKDC QQAKEAGHSV SGIYMIKPEN SNGPMQLWCE NSLDPGGWTV IQKRTDGSVN FFRNWENYKK GFGNIDGEYW LGLENIYMLS NQDNYKLLIE LEDWSDKKVY AEYSSFRLEP ESEFYRLRLG TYQGNAGDSM MWHNGKQFTT LDRDKDMYAG NCAHFHKGGW WYNACAHSNL NGVWYRGGHY RSKHQDGIFW AEYRGGSYSL RAVQMMIKPI D

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards