Guanylyl cyclase-activating protein 3 (GUCA1C)

About Guanylyl cyclase-activating protein 3

Guanylyl cyclase-activating protein 3 (GUCA1C) is a protein from Homo sapiens identified by UniProt accession O95843, 209 residues long. MolForge cross-references it against 0 known binders and 18 disease associations.

Target properties

Protein name	Guanylyl cyclase-activating protein 3
UniProt accession	O95843
Gene	GUCA1C
Organism	Homo sapiens
Length	209 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (18)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.28
antisocial behaviour measurement · score 0.20
substance abuse · score 0.20
attention deficit hyperactivity disorder · score 0.20
smoking status measurement · score 0.20
breast adenocarcinoma · score 0.11
high density lipoprotein cholesterol measurement · score 0.05
breast carcinoma · score 0.04
carcinoma of liver and intrahepatic biliary tract · score 0.02
pancreatic ductal adenocarcinoma · score 0.01

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O95843-F1	alphafold	PREDICTED	82.17	—

Amino-acid sequence (209 residues)

MGNGKSIAGD QKAVPTQETH VWYRTFMMEY PSGLQTLHEF KTLLGLQGLN QKANKHIDQV YNTFDTNKDG FVDFLEFIAA VNLIMQEKME QKLKWYFKLY DADGNGSIDK NELLDMFMAV QALNGQQTLS PEEFINLVFH KIDINNDGEL TLEEFINGMA KDQDLLEIVY KSFDFSNVLR VICNGKQPDM ETDSSKSPDK AGLGKVKMK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards