About Uridine diphosphate glucose pyrophosphatase NUDT14
Uridine diphosphate glucose pyrophosphatase NUDT14 (NUDT14) is a protein
from Homo sapiens identified by UniProt accession
O95848, 222 residues long.
MolForge cross-references it against 0 known binders and
28 disease associations.
Target properties
| Protein name | Uridine diphosphate glucose pyrophosphatase NUDT14 |
|---|
| UniProt accession | O95848 |
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| Gene | NUDT14 |
|---|
| Organism | Homo sapiens |
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| Length | 222 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (28)
Diseases linked to this target (Open Targets).
- neutrophil count · score 0.36
- reticulocyte count · score 0.35
- reticulocyte measurement · score 0.34
- leukocyte count · score 0.34
- myeloid white cell count · score 0.30
- Immature Reticulocyte Fraction Measurement · score 0.24
- cortical surface area measurement · score 0.18
- neuroimaging measurement · score 0.17
- cortical thickness · score 0.15
- brain measurement · score 0.15
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O95848-F1 | alphafold | PREDICTED | 94.69 | — |
Amino-acid sequence (222 residues)
MERIEGASVG RCAASPYLRP LTLHYRQNGA QKSWDFMKTH DSVTVLLFNS SRRSLVLVKQ FRPAVYAGEV ERRFPGSLAA VDQDGPRELQ PALPGSAGVT VELCAGLVDQ PGLSLEEVAC KEAWEECGYH LAPSDLRRVA TYWSGVGLTG SRQTMFYTEV TDAQRSGPGG GLVEEGELIE VVHLPLEGAQ AFADDPDIPK TLGVIFGVSW FLSQVAPNLD LQ
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