About Tetraspanin-12
Tetraspanin-12 (TSPAN12) is a protein
from Homo sapiens identified by UniProt accession
O95859, 305 residues long.
MolForge cross-references it against 0 known binders and
104 disease associations.
Target properties
| Protein name | Tetraspanin-12 |
|---|
| UniProt accession | O95859 |
|---|
| Gene | TSPAN12 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 305 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (104)
Diseases linked to this target (Open Targets).
- Familial exudative vitreoretinopathy · score 0.78
- bone density · score 0.36
- Vitreoretinopathy · score 0.34
- Norrie disease · score 0.34
- persistent hyperplastic primary vitreous, autosomal recessive · score 0.34
- Retinal dystrophy · score 0.30
- genetic disorder · score 0.18
- heel bone mineral density · score 0.13
- atopic eczema · score 0.11
- non-small cell lung carcinoma · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O95859-F1 | alphafold | PREDICTED | 80.29 | — |
Amino-acid sequence (305 residues)
MAREDSVKCL RCLLYALNLL FWLMSISVLA VSAWMRDYLN NVLTLTAETR VEEAVILTYF PVVHPVMIAV CCFLIIVGML GYCGTVKRNL LLLAWYFGSL LVIFCVELAC GVWTYEQELM VPVQWSDMVT LKARMTNYGL PRYRWLTHAW NFFQREFKCC GVVYFTDWLE MTEMDWPPDS CCVREFPGCS KQAHQEDLSD LYQEGCGKKM YSFLRGTKQL QVLRFLGISI GVTQILAMIL TITLLWALYY DRREPGTDQM MSLKNDNSQH LSCPSVELLK PSLSRIFEHT SMANSFNTHF EMEEL
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