3'(2'),5'-bisphosphate nucleotidase 1 (BPNT1)

About 3'(2'),5'-bisphosphate nucleotidase 1

3'(2'),5'-bisphosphate nucleotidase 1 (BPNT1) is a protein from Homo sapiens identified by UniProt accession O95861, 308 residues long. MolForge cross-references it against 0 known binders and 83 disease associations.

Target properties

Protein name	3'(2'),5'-bisphosphate nucleotidase 1
UniProt accession	O95861
Gene	BPNT1
Organism	Homo sapiens
Length	308 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (83)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.29
age at first birth measurement · score 0.16
mathematical ability · score 0.15
smoking status measurement · score 0.14
cortical surface area measurement · score 0.08
attention deficit hyperactivity disorder · score 0.07
antisocial behaviour measurement · score 0.07
substance abuse · score 0.07
progressive familial intrahepatic cholestasis · score 0.04
Congenital bile acid synthesis defect type 1 · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O95861-F1	alphafold	PREDICTED	96.42	—

Amino-acid sequence (308 residues)

MASSNTVLMR LVASAYSIAQ KAGMIVRRVI AEGDLGIVEK TCATDLQTKA DRLAQMSICS SLARKFPKLT IIGEEDLPSE EVDQELIEDS QWEEILKQPC PSQYSAIKEE DLVVWVDPLD GTKEYTEGLL DNVTVLIGIA YEGKAIAGVI NQPYYNYEAG PDAVLGRTIW GVLGLGAFGF QLKEVPAGKH IITTTRSHSN KLVTDCVAAM NPDAVLRVGG AGNKIIQLIE GKASAYVFAS PGCKKWDTCA PEVILHAVGG KLTDIHGNVL QYHKDVKHMN SAGVLATLRN YDYYASRVPE SIKNALVP

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards