Acyl-CoA 6-desaturase (FADS2)

About Acyl-CoA 6-desaturase

Acyl-CoA 6-desaturase (FADS2) is a protein from Homo sapiens identified by UniProt accession O95864, 444 residues long. MolForge cross-references it against 0 known binders and 446 disease associations.

Target properties

Protein name	Acyl-CoA 6-desaturase
UniProt accession	O95864
Gene	FADS2
Organism	Homo sapiens
Length	444 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (446)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.55
multiple sclerosis · score 0.47
lysosomal storage disease · score 0.46
Parkinson disease · score 0.46
Alzheimer disease · score 0.46
phosphatidylcholine measurement · score 0.40
phosphatidylethanolamine measurement · score 0.39
serum metabolite measurement · score 0.37
phosphatidylinositol measurement · score 0.37
blood metabolite measurement · score 0.37

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O95864-F1	alphafold	PREDICTED	94.98	—

Amino-acid sequence (444 residues)

MGKGGNQGEG AAEREVSVPT FSWEEIQKHN LRTDRWLVID RKVYNITKWS IQHPGGQRVI GHYAGEDATD AFRAFHPDLE FVGKFLKPLL IGELAPEEPS QDHGKNSKIT EDFRALRKTA EDMNLFKTNH VFFLLLLAHI IALESIAWFT VFYFGNGWIP TLITAFVLAT SQAQAGWLQH DYGHLSVYRK PKWNHLVHKF VIGHLKGASA NWWNHRHFQH HAKPNIFHKD PDVNMLHVFV LGEWQPIEYG KKKLKYLPYN HQHEYFFLIG PPLLIPMYFQ YQIIMTMIVH KNWVDLAWAV SYYIRFFITY IPFYGILGAL LFLNFIRFLE SHWFVWVTQM NHIVMEIDQE AYRDWFSSQL TATCNVEQSF FNDWFSGHLN FQIEHHLFPT MPRHNLHKIA PLVKSLCAKH GIEYQEKPLL RALLDIIRSL KKSGKLWLDA YLHK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards