About Megakaryocyte and platelet inhibitory receptor G6b
Megakaryocyte and platelet inhibitory receptor G6b (MPIG6B) is a protein
from Homo sapiens identified by UniProt accession
O95866, 241 residues long.
MolForge cross-references it against 0 known binders and
235 disease associations.
Target properties
| Protein name | Megakaryocyte and platelet inhibitory receptor G6b |
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| UniProt accession | O95866 |
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| Gene | MPIG6B |
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| Organism | Homo sapiens |
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| Length | 241 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (235)
Diseases linked to this target (Open Targets).
- thrombocytopenia, anemia, and myelofibrosis · score 0.66
- Thrombocytopenia · score 0.41
- blood platelet disease · score 0.37
- blood protein measurement · score 0.25
- platelet component distribution width · score 0.23
- platelet count · score 0.14
- Abnormal bleeding · score 0.14
- complement C4 measurement · score 0.12
- genetic disorder · score 0.12
- hypertension · score 0.11
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O95866-F1 | alphafold | PREDICTED | 73.19 | — |
Amino-acid sequence (241 residues)
MAVFLQLLPL LLSRAQGNPG ASLDGRPGDR VNLSCGGVSH PIRWVWAPSF PACKGLSKGR RPILWASSSG TPTVPPLQPF VGRLRSLDSG IRRLELLLSA GDSGTFFCKG RHEDESRTVL HVLGDRTYCK APGPTHGSVY PQLLIPLLGA GLVLGLGALG LVWWLHRRLP PQPIRPLPRF APLVKTEPQR PVKEEEPKIP GDLDQEPSLL YADLDHLALS RPRRLSTADP ADASTIYAVV V
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