About Phosphatidylserine lipase ABHD16A
Phosphatidylserine lipase ABHD16A (ABHD16A) is a protein
from Homo sapiens identified by UniProt accession
O95870, 558 residues long.
MolForge cross-references it against 0 known binders and
40 disease associations.
Target properties
| Protein name | Phosphatidylserine lipase ABHD16A |
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| UniProt accession | O95870 |
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| Gene | ABHD16A |
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| Organism | Homo sapiens |
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| Length | 558 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (40)
Diseases linked to this target (Open Targets).
- Spastic paraplegia · score 0.57
- Intellectual disability · score 0.53
- complex hereditary spastic paraplegia · score 0.42
- autosomal recessive complex spastic paraplegia · score 0.27
- genetic disorder · score 0.19
- Neurodevelopmental disorder · score 0.12
- blood protein measurement · score 0.08
- gonorrhea · score 0.04
- complement C4 measurement · score 0.03
- sphingolipid measurement · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O95870-F1 | alphafold | PREDICTED | 89.61 | — |
Amino-acid sequence (558 residues)
MAKLLSCVLG PRLYKIYRER DSERAPASVP ETPTAVTAPH SSSWDTYYQP RALEKHADSI LALASVFWSI SYYSSPFAFF YLYRKGYLSL SKVVPFSHYA GTLLLLLAGV ACLRGIGRWT NPQYRQFITI LEATHRNQSS ENKRQLANYN FDFRSWPVDF HWEEPSSRKE SRGGPSRRGV ALLRPEPLHR GTADTLLNRV KKLPCQITSY LVAHTLGRRM LYPGSVYLLQ KALMPVLLQG QARLVEECNG RRAKLLACDG NEIDTMFVDR RGTAEPQGQK LVICCEGNAG FYEVGCVSTP LEAGYSVLGW NHPGFAGSTG VPFPQNEANA MDVVVQFAIH RLGFQPQDII IYAWSIGGFT ATWAAMSYPD VSAMILDASF DDLVPLALKV MPDSWRGLVT RTVRQHLNLN NAEQLCRYQG PVLLIRRTKD EIITTTVPED IMSNRGNDLL LKLLQHRYPR VMAEEGLRVV RQWLEASSQL EEASIYSRWE VEEDWCLSVL RSYQAEHGPD FPWSVGEDMS ADGRRQLALF LARKHLHNFE ATHCTPLPAQ NFQMPWHL
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