About G patch domain and ankyrin repeat-containing protein 1
G patch domain and ankyrin repeat-containing protein 1 (GPANK1) is a protein
from Homo sapiens identified by UniProt accession
O95872, 356 residues long.
MolForge cross-references it against 0 known binders and
29 disease associations.
Target properties
| Protein name | G patch domain and ankyrin repeat-containing protein 1 |
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| UniProt accession | O95872 |
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| Gene | GPANK1 |
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| Organism | Homo sapiens |
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| Length | 356 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (29)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.25
- blood protein measurement · score 0.10
- glomerulonephritis · score 0.08
- hemoglobin measurement · score 0.06
- rosacea severity measurement · score 0.06
- hypertension · score 0.06
- systolic blood pressure · score 0.05
- serum gamma-glutamyl transferase measurement · score 0.05
- diastolic blood pressure · score 0.05
- age at menopause · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O95872-F1 | alphafold | PREDICTED | 71.39 | — |
Amino-acid sequence (356 residues)
MSRPLLITFT PATDPSDLWK DGQQQPQPEK PESTLDGAAA RAFYEALIGD ESSAPDSQRS QTEPARERKR KKRRIMKAPA AEAVAEGASG RHGQGRSLEA EDKMTHRILR AAQEGDLPEL RRLLEPHEAG GAGGNINARD AFWWTPLMCA ARAGQGAAVS YLLGRGAAWV GVCELSGRDA AQLAEEAGFP EVARMVRESH GETRSPENRS PTPSLQYCEN CDTHFQDSNH RTSTAHLLSL SQGPQPPNLP LGVPISSPGF KLLLRGGWEP GMGLGPRGEG RANPIPTVLK RDQEGLGYRS APQPRVTHFP AWDTRAVAGR ERPPRVATLS WREERRREEK DRAWERDLRT YMNLEF
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