About WD repeat-containing and planar cell polarity effector protein fritz homolog
WD repeat-containing and planar cell polarity effector protein fritz homolog (WDPCP) is a protein
from Homo sapiens identified by UniProt accession
O95876, 746 residues long.
MolForge cross-references it against 0 known binders and
134 disease associations.
Target properties
| Protein name | WD repeat-containing and planar cell polarity effector protein fritz homolog |
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| UniProt accession | O95876 |
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| Gene | WDPCP |
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| Organism | Homo sapiens |
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| Length | 746 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (134)
Diseases linked to this target (Open Targets).
- Bardet-Biedl syndrome 15 · score 0.72
- Heart defect-tongue hamartoma-polysyndactyly syndrome · score 0.67
- Bardet-Biedl syndrome · score 0.64
- heart defect - tongue hamartoma - polysyndactyly syndrome · score 0.61
- Meckel syndrome · score 0.52
- genetic disorder · score 0.47
- orofaciodigital syndrome · score 0.45
- blood protein measurement · score 0.27
- electrocardiography · score 0.23
- prostate carcinoma · score 0.22
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O95876-F1 | alphafold | PREDICTED | 76.32 | — |
Amino-acid sequence (746 residues)
MRREFCWDAY SKAAGSRASS PLPRQDRDSF CHQMSFCLTE LHLWSLKNTL HIADRDIGIY QYYDKKDPPA TEHGNLEKKQ KLAESRDYPW TLKNRRPEKL RDSLKELEEL MQNSRCVLSK WKNKYVCQLL FGSGVLVSLS LSGPQLEKVV IDRSLVGKLI SDTISDALLT DSFIILSFLA QNKLCFIQFT KKMESSDVNK RLEKLSALDY KIFYYEIPGP INKTTERHLA INCVHDRVVC WWPLVNDDAW PWAPISSEKD RANLLLLGYA QGRLEVLSSV RTEWDPLDVR FGTKQPYQVF TVEHSVSVDK EPMADSCIYE CIRNKIQCVS VTRIPLKSKA ISCCRNVTED KLILGCEDSS LILYETHRRV TLLAQTELLP SLISCHPSGA ILLVGSNQGE LQIFDMALSP INIQLLAEDR LPRETLQFSK LFDASSSLVQ MQWIAPQVVS QKGEGSDIYD LLFLRFERGP LGVLLFKLGV FTRGQLGLID IIFQYIHCDE IYEAINILSS MNWDTLGHQC FISMSAIVNH LLRQKLTPER EAQLETSLGT FYAPTRPLLD STILEYRDQI SKYARRFFHH LLRYQRFEKA FLLAVDVGAR DLFMDIHYLA LDKGELALAE VARKRASDID AESITSGVEL LGPLDRGDML NEAFIGLSLA PQGEDSFPDN LPPSCPTHRH ILQQRILNGS SNRQIIDRRN ELEKDICSGF LMTNTCNAED GELREDGREQ EIRDGGSLKM IHFGLV
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