Thioredoxin domain-containing protein 12 (TXNDC12)

About Thioredoxin domain-containing protein 12

Thioredoxin domain-containing protein 12 (TXNDC12) is a protein from Homo sapiens identified by UniProt accession O95881, 172 residues long. MolForge cross-references it against 0 known binders and 48 disease associations.

Target properties

Protein name	Thioredoxin domain-containing protein 12
UniProt accession	O95881
Gene	TXNDC12
Organism	Homo sapiens
Length	172 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (48)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.29
Parkinson disease · score 0.29
lysosomal storage disease · score 0.29
Alzheimer disease · score 0.29
multiple sclerosis · score 0.29
hepatocellular carcinoma · score 0.08
gonorrhea · score 0.07
pancreatic adenocarcinoma · score 0.07
neoplasm · score 0.06
cancer · score 0.03

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O95881-F1	alphafold	PREDICTED	87.44	—

Amino-acid sequence (172 residues)

METRPRLGAT CLLGFSFLLL VISSDGHNGL GKGFGDHIHW RTLEDGKKEA AASGLPLMVI IHKSWCGACK ALKPKFAEST EISELSHNFV MVNLEDEEEP KDEDFSPDGG YIPRILFLDP SGKVHPEIIN ENGNPSYKYF YVSAEQVVQG MKEAQERLTG DAFRKKHLED EL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards