Disks large-associated protein 3 (DLGAP3)

About Disks large-associated protein 3

Disks large-associated protein 3 (DLGAP3) is a protein from Homo sapiens identified by UniProt accession O95886, 979 residues long. MolForge cross-references it against 0 known binders and 38 disease associations.

Target properties

Protein name	Disks large-associated protein 3
UniProt accession	O95886
Gene	DLGAP3
Organism	Homo sapiens
Length	979 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (38)

Diseases linked to this target (Open Targets).

alcohol consumption measurement · score 0.29
neurodegenerative disease · score 0.23
thyroid gland adenocarcinoma · score 0.18
obsessive-compulsive disorder · score 0.04
anxiety · score 0.03
temporal lobe epilepsy · score 0.03
daytime rest measurement · score 0.02
hip bone size · score 0.02
cigarettes per day measurement · score 0.02
astrocytoma · score 0.01

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O95886-F1	alphafold	PREDICTED	50.14	—

Amino-acid sequence (979 residues)

MRGYHGDRGS HPRPARFADQ QHMDVGPAAR APYLLGSREA FSTEPRFCAP RAGLGHISPE GPLSLSEGPS VGPEGGPAGA GVGGGSSTFP RMYPGQGPFD TCEDCVGHPQ GKGAPRLPPT LLDQFEKQLP VQQDGFHTLP YQRGPAGAGP GPAPGTGTAP EPRSESPSRI RHLVHSVQKL FAKSHSLEAP GKRDYNGPKA EGRGGSGGDS YPGPGSGGPH TSHHHHHHHH HHHHQSRHGK RSKSKDRKGD GRHQAKSTGW WSSDDNLDSD SGFLAGGRPP GEPGGPFCLE GPDGSYRDLS FKGRSGGSEG RCLACTGMSM SLDGQSVKRS AWHTMMVSQG RDGYPGAGPG KGLLGPETKA KARTYHYLQV PQDDWGGYPT GGKDGEIPCR RMRSGSYIKA MGDEESGDSD GSPKTSPKAV ARRFTTRRSS SVDQARINCC VPPRIHPRSS IPGYSRSLTT GQLSDELNQQ LEAVCGSVFG ELESQAVDAL DLPGCFRMRS HSYLRAIQAG CSQDDDCLPL LATPAAVSGR PGSSFNFRKA PPPIPPGSQA PPRISITAQS STDSAHESFT AAEGPARRCS SADGLDGPAM GARTLELAPV PPRASPKPPT LIIKTIPGRE ELRSLARQRK WRPSIGVQVE TISDSDTENR SRREFHSIGV QVEEDKRRAR FKRSNSVTAG VQADLELEGL AGLATVATED KALQFGRSFQ RHASEPQPGP RAPTYSVFRT VHTQGQWAYR EGYPLPYEPP ATDGSPGPAP APTPGPGAGR RDSWIERGSR SLPDSGRASP CPRDGEWFIK MLRAEVEKLE HWCQQMEREA EDYELPEEIL EKIRSAVGST QLLLSQKVQQ FFRLCQQSMD PTAFPVPTFQ DLAGFWDLLQ LSIEDVTLKF LELQQLKANS WKLLEPKEEK KVPPPIPKKP LRGRGVPVKE RSLDSVDRQR QEARKRLLAA KRAASFRHSS ATESADSIEI YIPEAQTRL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards