Noelin-2 (OLFM2)

About Noelin-2

Noelin-2 (OLFM2) is a protein from Homo sapiens identified by UniProt accession O95897, 454 residues long. MolForge cross-references it against 0 known binders and 44 disease associations.

Target properties

Protein name	Noelin-2
UniProt accession	O95897
Gene	OLFM2
Organism	Homo sapiens
Length	454 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (44)

Diseases linked to this target (Open Targets).

vital capacity · score 0.32
age at menarche · score 0.31
self reported educational attainment · score 0.27
blood protein measurement · score 0.27
body fat percentage · score 0.26
sleep duration · score 0.25
body height · score 0.24
IGF-1 measurement · score 0.23
appendicular lean mass · score 0.22
BMI-adjusted waist-hip ratio · score 0.19

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O95897-F1	alphafold	PREDICTED	83.71	—

Amino-acid sequence (454 residues)

MWPLTVPPPL LLLLCSGLAG QTLFQNPEEG WQLYTSAQAP DGKCICTAVI PAQSTCSRDG RSRELRQLME KVQNVSQSME VLELRTYRDL QYVRGMETLM RSLDARLRAA DGSLSAKSFQ ELKDRMTELL PLSSVLEQYK ADTRTIVRLR EEVRNLSGSL AAIQEEMGAY GYEDLQQRVM ALEARLHACA QKLGCGKLTG VSNPITVRAM GSRFGSWMTD TMAPSADSRV WYMDGYYKGR RVLEFRTLGD FIKGQNFIQH LLPQPWAGTG HVVYNGSLFY NKYQSNVVVK YHFRSRSVLV QRSLPGAGYN NTFPYSWGGF SDMDFMVDES GLWAVYTTNQ NAGNIVVSRL DPHTLEVMRS WDTGYPKRSA GEAFMICGVL YVTNSHLAGA KVYFAYFTNT SSYEYTDVPF HNQYSHISML DYNPRERALY TWNNGHQVLY NVTLFHVIST SGDP

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards