Pseudouridylate synthase TRUB2, mitochondrial (TRUB2)

About Pseudouridylate synthase TRUB2, mitochondrial

Pseudouridylate synthase TRUB2, mitochondrial (TRUB2) is a protein from Homo sapiens identified by UniProt accession O95900, 331 residues long. MolForge cross-references it against 0 known binders and 25 disease associations.

Target properties

Protein name	Pseudouridylate synthase TRUB2, mitochondrial
UniProt accession	O95900
Gene	TRUB2
Organism	Homo sapiens
Length	331 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (25)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.37
hypertriglyceridemia 2 · score 0.06
body mass index · score 0.06
cholesterol-ester transfer protein deficiency · score 0.06
PHF-tau measurement · score 0.06
fat body mass · score 0.05
lean body mass · score 0.05
Combined hyperlipidemia · score 0.05
thyroid hormone metabolism, abnormal, 2 · score 0.04
sitosterolemia · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O95900-F1	alphafold	PREDICTED	85.36	—

Amino-acid sequence (331 residues)

MGSAGLSRLH GLFAVYKPPG LKWKHLRDTV ELQLLKGLNA RKPPAPKQRV RFLLGPMEGS EEKELTLTAT SVPSFINHPL VCGPAFAHLK VGVGHRLDAQ ASGVLVLGVG HGCRLLTDMY NAHLTKDYTV RGLLGKATDD FREDGRLVEK TTYDHVTREK LDRILAVIQG SHQKALVMYS NLDLKTQEAY EMAVRGLIRP MNKSPMLITG IRCLYFAPPE FLLEVQCMHE TQKELRKLVH EIGLELKTTA VCTQVRRTRD GFFTLDSALL RTQWDLTNIQ DAIRAATPQV AAELEKSLSP GLDTKQLPSP GWSWDSQGPS STLGLERGAG Q

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards