Monocarboxylate transporter 3 (SLC16A8)

About Monocarboxylate transporter 3

Monocarboxylate transporter 3 (SLC16A8) is a protein from Homo sapiens identified by UniProt accession O95907, 504 residues long. MolForge cross-references it against 0 known binders and 33 disease associations.

Target properties

Protein name	Monocarboxylate transporter 3
UniProt accession	O95907
Gene	SLC16A8
Organism	Homo sapiens
Length	504 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (33)

Diseases linked to this target (Open Targets).

age-related macular degeneration · score 0.29
white matter microstructure measurement · score 0.25
glioblastoma multiforme · score 0.23
central nervous system cancer · score 0.23
atrophic macular degeneration · score 0.21
wet macular degeneration · score 0.21
breast adenocarcinoma · score 0.18
head and neck squamous cell carcinoma · score 0.11
blood protein measurement · score 0.08
hearing loss · score 0.08

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O95907-F1	alphafold	PREDICTED	77.08	—

Amino-acid sequence (504 residues)

MGAGGPRRGE GPPDGGWGWV VLGACFVVTG FAYGFPKAVS VFFRALMRDF DAGYSDTAWV SSIMLAMLYG TGPVSSILVT RFGCRPVMLA GGLLASAGMI LASFATRLLE LYLTAGVLTG LGLALNFQPS LIMLGLYFER RRPLANGLAA AGSPVFLSAL SPLGQQLLER FGWRGGFLLL GGLLLHCCAC GAVMRPPPGP GPRPRRDSAG DRAGDAPGEA EADGAGLQLR EASPRVRPRR RLLDLAVCTD RAFAVYAVTK FLMALGLFVP AILLVNYAKD AGVPDTDAAF LLSIVGFVDI VARPACGALA GLARLRPHVP YLFSLALLAN GLTDLSSARA RSYGALVAFC VAFGLSYGMV GALQFEVLMA AVGAPRFPSA LGLVLLVEAA AVLIGPPSAG RLVDVLKNYE IIFYLAGSEV ALAGVFMAVA TNCCLRCAKA APSGPGTEGG ASDTEDAEAE GDSEPLPVVA EEPGNLEALE VLSARGEPTE PEIEARPRLA AESV

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards