Polyglutamylase complex subunit TTLL1 (TTLL1)

About Polyglutamylase complex subunit TTLL1

Polyglutamylase complex subunit TTLL1 (TTLL1) is a protein from Homo sapiens identified by UniProt accession O95922, 423 residues long. MolForge cross-references it against 0 known binders and 132 disease associations.

Target properties

Protein name	Polyglutamylase complex subunit TTLL1
UniProt accession	O95922
Gene	TTLL1
Organism	Homo sapiens
Length	423 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (132)

Diseases linked to this target (Open Targets).

urate measurement · score 0.31
bone density · score 0.31
platelet component distribution width · score 0.31
primary ovarian insufficiency · score 0.12
azoospermia · score 0.09
male infertility with teratozoospermia due to single gene mutation · score 0.07
spermatogenic failure 65 · score 0.07
prostate carcinoma · score 0.07
spermatogenic failure 56 · score 0.07
spermatogenic failure 51 · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O95922-F1	alphafold	PREDICTED	85.38	—

Amino-acid sequence (423 residues)

MAGKVKWVTD IEKSVLINNF EKRGWVQVTE NEDWNFYWMS VQTIRNVFSV EAGYRLSDDQ IVNHFPNHYE LTRKDLMVKN IKRYRKELEK EGSPLAEKDE NGKYLYLDFV PVTYMLPADY NLFVEEFRKS PSSTWIMKPC GKAQGKGIFL INKLSQIKKW SRDSKTSSFV SQSNKEAYVI SLYINNPLLI GGRKFDLRLY VLVSTYRPLR CYMYKLGFCR FCTVKYTPST SELDNMFVHL TNVAIQKHGE DYNHIHGGKW TVSNLRLYLE STRGKEVTSK LFDEIHWIIV QSLKAVAPVM NNDKHCFECY GYDIIIDDKL KPWLIEVNAS PSLTSSTAND RILKYNLIND TLNIAVPNGE IPDCKWNKSP PKEVLGNYEI LYDEELAQGD GADRELRSRQ GQSLGPRAGR SRDSGRAVLT TWK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards