About Protein-glutamine gamma-glutamyltransferase 6
Protein-glutamine gamma-glutamyltransferase 6 (TGM6) is a protein
from Homo sapiens identified by UniProt accession
O95932, 706 residues long.
MolForge cross-references it against 0 known binders and
92 disease associations.
Target properties
| Protein name | Protein-glutamine gamma-glutamyltransferase 6 |
|---|
| UniProt accession | O95932 |
|---|
| Gene | TGM6 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 706 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (92)
Diseases linked to this target (Open Targets).
- spinocerebellar ataxia type 35 · score 0.77
- inherited acute myeloid leukemia · score 0.37
- acute myeloid leukemia · score 0.33
- tuberculosis · score 0.31
- Alzheimer disease · score 0.30
- metabolite measurement · score 0.22
- genetic disorder · score 0.19
- Parkinson disease · score 0.12
- Oculomotor apraxia · score 0.12
- Rigidity · score 0.12
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O95932-F1 | alphafold | PREDICTED | 91.05 | — |
Amino-acid sequence (706 residues)
MAGIRVTKVD WQRSRNGAAH HTQEYPCPEL VVRRGQSFSL TLELSRALDC EEILIFTMET GPRASEALHT KAVFQTSELE RGEGWTAARE AQMEKTLTVS LASPPSAVIG RYLLSIRLSS HRKHSNRRLG EFVLLFNPWC AEDDVFLASE EERQEYVLSD SGIIFRGVEK HIRAQGWNYG QFEEDILNIC LSILDRSPGH QNNPATDVSC RHNPIYVTRV ISAMVNSNND RGVVQGQWQG KYGGGTSPLH WRGSVAILQK WLKGRYKPVK YGQCWVFAGV LCTVLRCLGI ATRVVSNFNS AHDTDQNLSV DKYVDSFGRT LEDLTEDSMW NFHVWNESWF ARQDLGPSYN GWQVLDATPQ EESEGVFRCG PASVTAIREG DVHLAHDGPF VFAEVNADYI TWLWHEDESR ERVYSNTKKI GRCISTKAVG SDSRVDITDL YKYPEGSRKE RQVYSKAVNR LFGVEASGRR IWIRRAGGRC LWRDDLLEPA TKPSIAGKFK VLEPPMLGHD LRLALCLANL TSRAQRVRVN LSGATILYTR KPVAEILHES HAVRLGPQEE KRIPITISYS KYKEDLTEDK KILLAAMCLV TKGEKLLVEK DITLEDFITI KVLGPAMVGV AVTVEVTVVN PLIERVKDCA LMVEGSGLLQ EQLSIDVPTL EPQERASVQF DITPSKSGPR QLQVDLVSPH FPDIKGFVIV HVATAK
Explore Protein-glutamine gamma-glutamyltransferase 6 with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets