About T-box transcription factor TBX18
T-box transcription factor TBX18 (TBX18) is a protein
from Homo sapiens identified by UniProt accession
O95935, 607 residues long.
MolForge cross-references it against 0 known binders and
119 disease associations.
Target properties
| Protein name | T-box transcription factor TBX18 |
|---|
| UniProt accession | O95935 |
|---|
| Gene | TBX18 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 607 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (119)
Diseases linked to this target (Open Targets).
- congenital hydronephrosis · score 0.73
- congenital anomaly of kidney and urinary tract · score 0.54
- neurodegenerative disease · score 0.52
- BMI-adjusted waist-hip ratio · score 0.47
- body height · score 0.46
- waist-hip ratio · score 0.44
- BMI-adjusted waist circumference · score 0.43
- appendicular lean mass · score 0.41
- pulse pressure measurement · score 0.37
- gallbladder disease · score 0.31
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O95935-F1 | alphafold | PREDICTED | 59.43 | — |
Amino-acid sequence (607 residues)
MAEKRRGSPC SMLSLKAHAF SVEALIGAEK QQQLQKKRRK LGAEEAAGAV DDGGCSRGGG AGEKGSSEGD EGAALPPPAG ATSGPARSGA DLERGAAGGC EDGFQQGASP LASPGGSPKG SPARSLARPG TPLPSPQAPR VDLQGAELWK RFHEIGTEMI ITKAGRRMFP AMRVKISGLD PHQQYYIAMD IVPVDNKRYR YVYHSSKWMV AGNADSPVPP RVYIHPDSPA SGETWMRQVI SFDKLKLTNN ELDDQGHIIL HSMHKYQPRV HVIRKDCGDD LSPIKPVPSG EGVKAFSFPE TVFTTVTAYQ NQQITRLKID RNPFAKGFRD SGRNRMGLEA LVESYAFWRP SLRTLTFEDI PGIPKQGNAS SSTLLQGTGN GVPATHPHLL SGSSCSSPAF HLGPNTSQLC SLAPADYSAC ARSGLTLNRY STSLAETYNR LTNQAGETFA PPRTPSYVGV SSSTSVNMSM GGTDGDTFSC PQTSLSMQIS GMSPQLQYIM PSPSSNAFAT NQTHQGSYNT FRLHSPCALY GYNFSTSPKL AASPEKIVSS QGSFLGSSPS GTMTDRQMLP PVEGVHLLSS GGQQSFFDSR TLGSLTLSSS QVSAHMV
Explore T-box transcription factor TBX18 with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets