About Natural cytotoxicity triggering receptor 2
Natural cytotoxicity triggering receptor 2 (NCR2) is a protein
from Homo sapiens identified by UniProt accession
O95944, 276 residues long.
MolForge cross-references it against 0 known binders and
127 disease associations.
Target properties
| Protein name | Natural cytotoxicity triggering receptor 2 |
|---|
| UniProt accession | O95944 |
|---|
| Gene | NCR2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 276 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (127)
Diseases linked to this target (Open Targets).
- p-tau measurement · score 0.18
- Alzheimer disease · score 0.18
- hair shape measurement · score 0.12
- balding measurement · score 0.12
- PHF-tau measurement · score 0.11
- hair colour measurement · score 0.10
- Rheumatoid arthritis · score 0.08
- neoplasm · score 0.07
- acute myeloid leukemia · score 0.06
- reticulocyte count · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O95944-F1 | alphafold | PREDICTED | 74.33 | — |
Amino-acid sequence (276 residues)
MAWRALHPLL LLLLLFPGSQ AQSKAQVLQS VAGQTLTVRC QYPPTGSLYE KKGWCKEASA LVCIRLVTSS KPRTMAWTSR FTIWDDPDAG FFTVTMTDLR EEDSGHYWCR IYRPSDNSVS KSVRFYLVVS PASASTQTSW TPRDLVSSQT QTQSCVPPTA GARQAPESPS TIPVPSQPQN STLRPGPAAP IALVPVFCGL LVAKSLVLSA LLVWWGDIWW KTMMELRSLD TQKATCHLQQ VTDLPWTSVS SPVEREILYH TVARTKISDD DDEHTL
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