T-box transcription factor TBX6 (TBX6)

About T-box transcription factor TBX6

T-box transcription factor TBX6 (TBX6) is a protein from Homo sapiens identified by UniProt accession O95947, 436 residues long. MolForge cross-references it against 0 known binders and 199 disease associations.

Target properties

Protein name	T-box transcription factor TBX6
UniProt accession	O95947
Gene	TBX6
Organism	Homo sapiens
Length	436 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (199)

Diseases linked to this target (Open Targets).

autosomal dominant spondylocostal dysostosis · score 0.71
scoliosis · score 0.52
genetic disorder · score 0.45
eosinophil count · score 0.30
mean corpuscular volume · score 0.30
erythrocyte count · score 0.29
mean corpuscular hemoglobin · score 0.28
mean corpuscular hemoglobin concentration · score 0.28
hemoglobin measurement · score 0.28
hematocrit · score 0.27

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O95947-F1	alphafold	PREDICTED	64.63	—

Amino-acid sequence (436 residues)

MYHPRELYPS LGAGYRLGPA QPGADSSFPP ALAEGYRYPE LDTPKLDCFL SGMEAAPRTL AAHPPLPLLP PAMGTEPAPS APEALHSLPG VSLSLENREL WKEFSSVGTE MIITKAGRRM FPACRVSVTG LDPEARYLFL LDVIPVDGAR YRWQGRRWEP SGKAEPRLPD RVYIHPDSPA TGAHWMRQPV SFHRVKLTNS TLDPHGHLIL HSMHKYQPRI HLVRAAQLCS QHWGGMASFR FPETTFISVT AYQNPQITQL KIAANPFAKG FRENGRNCKR ERDARVKRKL RGPEPAATEA YGSGDTPGGP CDSTLGGDIR ESDPEQAPAP GEATAAPAPL CGGPSAEAYL LHPAAFHGAP SHLPTRSPSF PEAPDSGRSA PYSAAFLELP HGSGGSGYPA APPAVPFAPH FLQGGPFPLP YTAPGGYLDV GSKPMY

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards