About One cut domain family member 2
One cut domain family member 2 (ONECUT2) is a protein
from Homo sapiens identified by UniProt accession
O95948, 504 residues long.
MolForge cross-references it against 0 known binders and
119 disease associations.
Target properties
| Protein name | One cut domain family member 2 |
|---|
| UniProt accession | O95948 |
|---|
| Gene | ONECUT2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 504 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (119)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.53
- aspartate aminotransferase measurement · score 0.45
- sex hormone-binding globulin measurement · score 0.41
- C-reactive protein measurement · score 0.40
- lysosomal storage disease · score 0.37
- alkaline phosphatase measurement · score 0.33
- Headache · score 0.33
- serum gamma-glutamyl transferase measurement · score 0.33
- total blood protein measurement · score 0.33
- alcohol consumption measurement · score 0.31
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O95948-F1 | alphafold | PREDICTED | 57.53 | — |
Amino-acid sequence (504 residues)
MKAAYTAYRC LTKDLEGCAM NPELTMESLG TLHGPAGGGS GGGGGGGGGG GGGGPGHEQE LLASPSPHHA GRGAAGSLRG PPPPPTAHQE LGTAAAAAAA ASRSAMVTSM ASILDGGDYR PELSIPLHHA MSMSCDSSPP GMGMSNTYTT LTPLQPLPPI STVSDKFHHP HPHHHPHHHH HHHHQRLSGN VSGSFTLMRD ERGLPAMNNL YSPYKEMPGM SQSLSPLAAT PLGNGLGGLH NAQQSLPNYG PPGHDKMLSP NFDAHHTAML TRGEQHLSRG LGTPPAAMMS HLNGLHHPGH TQSHGPVLAP SRERPPSSSS GSQVATSGQL EEINTKEVAQ RITAELKRYS IPQAIFAQRV LCRSQGTLSD LLRNPKPWSK LKSGRETFRR MWKWLQEPEF QRMSALRLAA CKRKEQEPNK DRNNSQKKSR LVFTDLQRRT LFAIFKENKR PSKEMQITIS QQLGLELTTV SNFFMNARRR SLEKWQDDLS TGGSSSTSST CTKA
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