About EGF-containing fibulin-like extracellular matrix protein 2
EGF-containing fibulin-like extracellular matrix protein 2 (EFEMP2) is a protein
from Homo sapiens identified by UniProt accession
O95967, 443 residues long.
MolForge cross-references it against 0 known binders and
212 disease associations.
Target properties
| Protein name | EGF-containing fibulin-like extracellular matrix protein 2 |
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| UniProt accession | O95967 |
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| Gene | EFEMP2 |
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| Organism | Homo sapiens |
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| Length | 443 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (212)
Diseases linked to this target (Open Targets).
- autosomal recessive cutis laxa type 1 · score 0.66
- Abnormality of the cardiovascular system · score 0.47
- aortic aneurysm · score 0.47
- lethal arteriopathy syndrome due to fibulin-4 deficiency · score 0.37
- neurodegenerative disease · score 0.32
- cutis laxa · score 0.27
- familial thoracic aortic aneurysm and aortic dissection · score 0.22
- lung adenocarcinoma · score 0.21
- eosinophil count · score 0.19
- body mass index · score 0.19
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O95967-F1 | alphafold | PREDICTED | 82.37 | — |
Amino-acid sequence (443 residues)
MLPCASCLPG SLLLWALLLL LLGSASPQDS EEPDSYTECT DGYEWDPDSQ HCRDVNECLT IPEACKGEMK CINHYGGYLC LPRSAAVIND LHGEGPPPPV PPAQHPNPCP PGYEPDDQDS CVDVDECAQA LHDCRPSQDC HNLPGSYQCT CPDGYRKIGP ECVDIDECRY RYCQHRCVNL PGSFRCQCEP GFQLGPNNRS CVDVNECDMG APCEQRCFNS YGTFLCRCHQ GYELHRDGFS CSDIDECSYS SYLCQYRCIN EPGRFSCHCP QGYQLLATRL CQDIDECESG AHQCSEAQTC VNFHGGYRCV DTNRCVEPYI QVSENRCLCP ASNPLCREQP SSIVHRYMTI TSERSVPADV FQIQATSVYP GAYNAFQIRA GNSQGDFYIR QINNVSAMLV LARPVTGPRE YVLDLEMVTM NSLMSYRASS VLRLTVFVGA YTF
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