About Leucine-rich glioma-inactivated protein 1
Leucine-rich glioma-inactivated protein 1 (LGI1) is a protein
from Homo sapiens identified by UniProt accession
O95970, 557 residues long.
MolForge cross-references it against 0 known binders and
343 disease associations.
Target properties
| Protein name | Leucine-rich glioma-inactivated protein 1 |
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| UniProt accession | O95970 |
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| Gene | LGI1 |
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| Organism | Homo sapiens |
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| Length | 557 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (343)
Diseases linked to this target (Open Targets).
- autosomal dominant epilepsy with auditory features · score 0.74
- Seizure · score 0.45
- genetic disorder · score 0.38
- genitopatellar syndrome · score 0.34
- Bilateral tonic-clonic seizure · score 0.12
- Intellectual disability · score 0.12
- encephalitis · score 0.12
- generalised epilepsy · score 0.09
- temporal lobe epilepsy · score 0.09
- Benign familial neonatal seizures · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O95970-F1 | alphafold | PREDICTED | 92.56 | — |
Amino-acid sequence (557 residues)
MESERSKRMG NACIPLKRIA YFLCLLSALL LTEGKKPAKP KCPAVCTCTK DNALCENARS IPRTVPPDVI SLSFVRSGFT EISEGSFLFT PSLQLLLFTS NSFDVISDDA FIGLPHLEYL FIENNNIKSI SRHTFRGLKS LIHLSLANNN LQTLPKDIFK GLDSLTNVDL RGNSFNCDCK LKWLVEWLGH TNATVEDIYC EGPPEYKKRK INSLSSKDFD CIITEFAKSQ DLPYQSLSID TFSYLNDEYV VIAQPFTGKC IFLEWDHVEK TFRNYDNITG TSTVVCKPIV IETQLYVIVA QLFGGSHIYK RDSFANKFIK IQDIEILKIR KPNDIETFKI ENNWYFVVAD SSKAGFTTIY KWNGNGFYSH QSLHAWYRDT DVEYLEIVRT PQTLRTPHLI LSSSSQRPVI YQWNKATQLF TNQTDIPNME DVYAVKHFSV KGDVYICLTR FIGDSKVMKW GGSSFQDIQR MPSRGSMVFQ PLQINNYQYA ILGSDYSFTQ VYNWDAEKAK FVKFQELNVQ APRSFTHVSI NKRNFLFASS FKGNTQIYKH VIVDLSA
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