Bone morphogenetic protein 15 (BMP15)

About Bone morphogenetic protein 15

Bone morphogenetic protein 15 (BMP15) is a protein from Homo sapiens identified by UniProt accession O95972, 392 residues long. MolForge cross-references it against 0 known binders and 92 disease associations.

Target properties

Protein name	Bone morphogenetic protein 15
UniProt accession	O95972
Gene	BMP15
Organism	Homo sapiens
Length	392 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (92)

Diseases linked to this target (Open Targets).

46,XX gonadal dysgenesis · score 0.81
primary ovarian insufficiency · score 0.57
premature menopause · score 0.38
Premature ovarian insufficiency · score 0.37
Primary amenorrhea · score 0.34
genetic non-acquired premature ovarian failure · score 0.32
neurodegenerative disease · score 0.22
genetic disorder · score 0.19
polycystic ovary syndrome · score 0.12
46,XY complete gonadal dysgenesis · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O95972-F1	alphafold	PREDICTED	71.85	—

Amino-acid sequence (392 residues)

MVLLSILRIL FLCELVLFME HRAQMAEGGQ SSIALLAEAP TLPLIEELLE ESPGEQPRKP RLLGHSLRYM LELYRRSADS HGHPRENRTI GATMVRLVKP LTNVARPHRG TWHIQILGFP LRPNRGLYQL VRATVVYRHH LQLTRFNLSC HVEPWVQKNP TNHFPSSEGD SSKPSLMSNA WKEMDITQLV QQRFWNNKGH RILRLRFMCQ QQKDSGGLEL WHGTSSLDIA FLLLYFNDTH KSIRKAKFLP RGMEEFMERE SLLRRTRQAD GISAEVTASS SKHSGPENNQ CSLHPFQISF RQLGWDHWII APPFYTPNYC KGTCLRVLRD GLNSPNHAII QNLINQLVDQ SVPRPSCVPY KYVPISVLMI EANGSILYKE YEGMIAESCT CR

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards