Sphingosine 1-phosphate receptor 4 (S1PR4)

About Sphingosine 1-phosphate receptor 4

Sphingosine 1-phosphate receptor 4 (S1PR4) is a protein from Homo sapiens identified by UniProt accession O95977, 384 residues long. MolForge cross-references it against 0 known binders and 135 disease associations.

Target properties

Protein name	Sphingosine 1-phosphate receptor 4
UniProt accession	O95977
Gene	S1PR4
Organism	Homo sapiens
Length	384 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (5)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (135)

Diseases linked to this target (Open Targets).

leukocyte count · score 0.64
neutrophil count · score 0.61
monocyte count · score 0.61
eosinophil count · score 0.60
multiple sclerosis · score 0.59
relapsing-remitting multiple sclerosis · score 0.59
ulcerative colitis · score 0.54
basophil percentage of leukocytes · score 0.53
eosinophil percentage of leukocytes · score 0.52
lymphocyte count · score 0.44

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O95977-F1	alphafold	PREDICTED	78.37	—

Amino-acid sequence (384 residues)

MNATGTPVAP ESCQQLAAGG HSRLIVLHYN HSGRLAGRGG PEDGGLGALR GLSVAASCLV VLENLLVLAA ITSHMRSRRW VYYCLVNITL SDLLTGAAYL ANVLLSGART FRLAPAQWFL REGLLFTALA ASTFSLLFTA GERFATMVRP VAESGATKTS RVYGFIGLCW LLAALLGMLP LLGWNCLCAF DRCSSLLPLY SKRYILFCLV IFAGVLATIM GLYGAIFRLV QASGQKAPRP AARRKARRLL KTVLMILLAF LVCWGPLFGL LLADVFGSNL WAQEYLRGMD WILALAVLNS AVNPIIYSFR SREVCRAVLS FLCCGCLRLG MRGPGDCLAR AVEAHSGAST TDSSLRPRDS FRGSRSLSFR MREPLSSISS VRSI

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards