About Methyl-CpG-binding domain protein 3
Methyl-CpG-binding domain protein 3 (MBD3) is a protein
from Homo sapiens identified by UniProt accession
O95983, 291 residues long.
MolForge cross-references it against 0 known binders and
24 disease associations.
Target properties
| Protein name | Methyl-CpG-binding domain protein 3 |
|---|
| UniProt accession | O95983 |
|---|
| Gene | MBD3 |
|---|
| Organism | Homo sapiens |
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| Length | 291 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (24)
Diseases linked to this target (Open Targets).
- breast adenocarcinoma · score 0.27
- neurodegenerative disease · score 0.27
- ovarian cancer · score 0.23
- gastric adenocarcinoma · score 0.19
- lung adenocarcinoma · score 0.18
- esophageal cancer · score 0.18
- head and neck squamous cell carcinoma · score 0.18
- neoplasm · score 0.08
- hepatocellular carcinoma · score 0.07
- gonorrhea · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O95983-F1 | alphafold | PREDICTED | 78.76 | — |
Amino-acid sequence (291 residues)
MERKRWECPA LPQGWEREEV PRRSGLSAGH RDVFYYSPSG KKFRSKPQLA RYLGGSMDLS TFDFRTGKML MSKMNKSRQR VRYDSSNQVK GKPDLNTALP VRQTASIFKQ PVTKITNHPS NKVKSDPQKA VDQPRQLFWE KKLSGLNAFD IAEELVKTMD LPKGLQGVGP GCTDETLLSA IASALHTSTM PITGQLSAAV EKNPGVWLNT TQPLCKAFMV TDEDIRKQEE LVQQVRKRLE EALMADMLAH VEELARDGEA PLDKACAEDD DEEDEEEEEE EPDPDPEMEH V
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