T-cell leukemia/lymphoma protein 1B (TCL1B)

About T-cell leukemia/lymphoma protein 1B

T-cell leukemia/lymphoma protein 1B (TCL1B) is a protein from Homo sapiens identified by UniProt accession O95988, 128 residues long. MolForge cross-references it against 0 known binders and 83 disease associations.

Target properties

Protein name	T-cell leukemia/lymphoma protein 1B
UniProt accession	O95988
Gene	TCL1B
Organism	Homo sapiens
Length	128 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (83)

Diseases linked to this target (Open Targets).

Abnormality of refraction · score 0.26
grey matter volume measurement · score 0.12
cancer · score 0.07
acute respiratory distress syndrome · score 0.06
platelet count · score 0.05
neoplasm · score 0.05
dimethylglycine measurement · score 0.05
Anal fissure · score 0.05
Waldenstrom macroglobulinemia · score 0.04
Herpes simplex infection · score 0.03

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O95988-F1	alphafold	PREDICTED	78.72	—

Amino-acid sequence (128 residues)

MASEASVRLG VPPGRLWIQR PGIYEDEEGR TWVTVVVRFN PSRREWARAS QGSRYEPSIT VHLWQMAVHT RELLSSGQMP FSQLPAVWQL YPGRKYRAAD SSFWEIADHG QIDSMEQLVL TYQPERKD

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards