Diphosphoinositol polyphosphate phosphohydrolase 1…

About Diphosphoinositol polyphosphate phosphohydrolase 1

Diphosphoinositol polyphosphate phosphohydrolase 1 (NUDT3) is a protein from Homo sapiens identified by UniProt accession O95989, 172 residues long. MolForge cross-references it against 0 known binders and 80 disease associations.

Target properties

Protein name	Diphosphoinositol polyphosphate phosphohydrolase 1
UniProt accession	O95989
Gene	NUDT3
Organism	Homo sapiens
Length	172 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (80)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.45
lean body mass · score 0.38
fat body mass · score 0.34
reticulocyte count · score 0.27
heel bone mineral density · score 0.26
body mass index · score 0.23
reticulocyte measurement · score 0.23
sex hormone-binding globulin measurement · score 0.20
lymphocyte count · score 0.20
appendicular lean mass · score 0.16

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O95989-F1	alphafold	PREDICTED	86.76	—

Amino-acid sequence (172 residues)

MMKLKSNQTR TYDGDGYKKR AACLCFRSES EEEVLLVSSS RHPDRWIVPG GGMEPEEEPS VAAVREVCEE AGVKGTLGRL VGIFENQERK HRTYVYVLIV TEVLEDWEDS VNIGRKREWF KIEDAIKVLQ YHKPVQASYF ETLRQGYSAN NGTPVVATTY SVSAQSSMSG IR

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

Diphosphoinositol polyphosphate phosphohydrolase 1 (NUDT3)