About Cholesterol 25-hydroxylase
Cholesterol 25-hydroxylase (CH25H) is a protein
from Homo sapiens identified by UniProt accession
O95992, 272 residues long.
MolForge cross-references it against 0 known binders and
239 disease associations.
Target properties
| Protein name | Cholesterol 25-hydroxylase |
|---|
| UniProt accession | O95992 |
|---|
| Gene | CH25H |
|---|
| Organism | Homo sapiens |
|---|
| Length | 272 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (239)
Diseases linked to this target (Open Targets).
- inflammatory bowel disease · score 0.23
- protein measurement · score 0.19
- serum non-albumin protein measurement · score 0.12
- eosinophil count · score 0.11
- blood protein measurement · score 0.09
- total blood protein measurement · score 0.09
- coronary artery disease · score 0.09
- C-reactive protein measurement · score 0.09
- neoplasm · score 0.08
- neutrophil count · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O95992-F1 | alphafold | PREDICTED | 91.74 | — |
Amino-acid sequence (272 residues)
MSCHNCSDPQ VLCSSGQLFL QPLWDHLRSW EALLQSPFFP VIFSITTYVG FCLPFVVLDI LCSWVPALRR YKIHPDFSPS AQQLLPCLGQ TLYQHVMFVF PVTLLHWARS PALLPHEAPE LLLLLHHILF CLLLFDMEFF VWHLLHHKVP WLYRTFHKVH HQNSSSFALA TQYMSVWELF SLGFFDMMNV TLLGCHPLTT LTFHVVNIWL SVEDHSGYNF PWSTHRLVPF GWYGGVVHHD LHHSHFNCNF APYFTHWDKI LGTLRTASVP AR
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