About Anterior gradient protein 2 homolog
Anterior gradient protein 2 homolog (AGR2) is a protein
from Homo sapiens identified by UniProt accession
O95994, 175 residues long.
MolForge cross-references it against 0 known binders and
297 disease associations.
Target properties
| Protein name | Anterior gradient protein 2 homolog |
|---|
| UniProt accession | O95994 |
|---|
| Gene | AGR2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 175 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (297)
Diseases linked to this target (Open Targets).
- respiratory infections, recurrent, and failure to thrive with or without diarrhea · score 0.62
- chronic diarrheal disease · score 0.46
- Chronic diarrhea · score 0.46
- protein measurement · score 0.31
- neoplasm · score 0.12
- cancer · score 0.11
- hepatocellular carcinoma · score 0.11
- lung adenocarcinoma · score 0.10
- pancreatic neoplasm · score 0.09
- inflammatory bowel disease · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O95994-F1 | alphafold | PREDICTED | 86.18 | — |
Amino-acid sequence (175 residues)
MEKIPVSAFL LLVALSYTLA RDTTVKPGAK KDTKDSRPKL PQTLSRGWGD QLIWTQTYEE ALYKSKTSNK PLMIIHHLDE CPHSQALKKV FAENKEIQKL AEQFVLLNLV YETTDKHLSP DGQYVPRIMF VDPSLTVRAD ITGRYSNRLY AYEPADTALL LDNMKKALKL LKTEL
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