Dynein regulatory complex subunit 4 (DRC4)

About Dynein regulatory complex subunit 4

Dynein regulatory complex subunit 4 (DRC4) is a protein from Homo sapiens identified by UniProt accession O95995, 478 residues long. MolForge cross-references it against 0 known binders and 93 disease associations.

Target properties

Protein name	Dynein regulatory complex subunit 4
UniProt accession	O95995
Gene	DRC4
Organism	Homo sapiens
Length	478 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (93)

Diseases linked to this target (Open Targets).

primary ciliary dyskinesia · score 0.69
hair colour measurement · score 0.50
skin pigmentation · score 0.47
hair color · score 0.41
cancer · score 0.33
skin pigmentation measurement · score 0.33
sunburn · score 0.25
suntan · score 0.24
neurodegenerative disease · score 0.23
mathematical ability · score 0.21

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O95995-F1	alphafold	PREDICTED	84.45	—

Amino-acid sequence (478 residues)

MAPKKKGKKG KAKGTPIVDG LAPEDMSKEQ VEEHVSRIRE ELDREREERN YFQLERDKIH TFWEITRRQL EEKKAELRNK DREMEEAEER HQVEIKVYKQ KVKHLLYEHQ NNLTEMKAEG TVVMKLAQKE HRIQESVLRK DMRALKVELK EQELASEVVV KNLRLKHTEE ITRMRNDFER QVREIEAKYD KKMKMLRDEL DLRRKTELHE VEERKNGQIH TLMQRHEEAF TDIKNYYNDI TLNNLALINS LKEQMEDMRK KEDHLEREMA EVSGQNKRLA DPLQKAREEM SEMQKQLANY ERDKQILLCT KARLKVREKE LKDLQWEHEV LEQRFTKVQQ ERDELYRKFT AAIQEVQQKT GFKNLVLERK LQALSAAVEK KEVQFNEVLA ASNLDPAALT LVSRKLEDVL ESKNSTIKDL QYELAQVCKA HNDLLRTYEA KLLAFGIPLD NVGFKPLETA VIGQTLGQGP AGLVGTPT

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards