About Securin
Securin (PTTG1) is a protein
from Homo sapiens identified by UniProt accession
O95997, 202 residues long.
MolForge cross-references it against 0 known binders and
303 disease associations.
Target properties
| Protein name | Securin |
|---|
| UniProt accession | O95997 |
|---|
| Gene | PTTG1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 202 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (303)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.55
- eosinophil count · score 0.38
- systemic lupus erythematosus · score 0.31
- asthma · score 0.31
- eosinophil percentage of leukocytes · score 0.30
- allergic rhinitis · score 0.29
- Eczematoid dermatitis · score 0.29
- adolescent idiopathic scoliosis · score 0.27
- seasonal allergic rhinitis · score 0.21
- Inhalant adrenergic use measurement · score 0.21
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O95997-F1 | alphafold | PREDICTED | 63.15 | — |
Amino-acid sequence (202 residues)
MATLIYVDKE NGEPGTRVVA KDGLKLGSGP SIKALDGRSQ VSTPRFGKTF DAPPALPKAT RKALGTVNRA TEKSVKTKGP LKQKQPSFSA KKMTEKTVKA KSSVPASDDA YPEIEKFFPF NPLDFESFDL PEEHQIAHLP LSGVPLMILD EERELEKLFQ LGPPSPVKMP SPPWESNLLQ SPSSILSTLD VELPPVCCDI DI
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