About Interleukin-18-binding protein
Interleukin-18-binding protein (IL18BP) is a protein
from Homo sapiens identified by UniProt accession
O95998, 194 residues long.
MolForge cross-references it against 0 known binders and
361 disease associations.
Target properties
| Protein name | Interleukin-18-binding protein |
|---|
| UniProt accession | O95998 |
|---|
| Gene | IL18BP |
|---|
| Organism | Homo sapiens |
|---|
| Length | 194 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (361)
Diseases linked to this target (Open Targets).
- mean platelet volume · score 0.09
- neoplasm · score 0.09
- immature platelet fraction · score 0.07
- urinary albumin to creatinine ratio · score 0.07
- gastric adenocarcinoma · score 0.07
- calcium measurement · score 0.07
- cryopyrin-associated periodic syndrome · score 0.06
- Familial hemophagocytic lymphohistiocytosis · score 0.06
- body height · score 0.06
- adult-onset Still's disease · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O95998-F1 | alphafold | PREDICTED | 79.08 | — |
Amino-acid sequence (194 residues)
MTMRHNWTPD LSPLWVLLLC AHVVTLLVRA TPVSQTTTAA TASVRSTKDP CPSQPPVFPA AKQCPALEVT WPEVEVPLNG TLSLSCVACS RFPNFSILYW LGNGSFIEHL PGRLWEGSTS RERGSTGTQL CKALVLEQLT PALHSTNFSC VLVDPEQVVQ RHVVLAQLWA GLRATLPPTQ EALPSSHSSP QQQG
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