About B-cell lymphoma/leukemia 10
B-cell lymphoma/leukemia 10 (BCL10) is a protein
from Homo sapiens identified by UniProt accession
O95999, 233 residues long.
MolForge cross-references it against 0 known binders and
412 disease associations.
Target properties
| Protein name | B-cell lymphoma/leukemia 10 |
|---|
| UniProt accession | O95999 |
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| Gene | BCL10 |
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| Organism | Homo sapiens |
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| Length | 233 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (412)
Diseases linked to this target (Open Targets).
- immunodeficiency 37 · score 0.64
- MALT lymphoma · score 0.56
- follicular lymphoma · score 0.50
- diffuse large B-cell lymphoma · score 0.47
- mesothelioma · score 0.42
- lung carcinoma · score 0.37
- Testicular Germ Cell Tumor · score 0.36
- colon carcinoma · score 0.33
- T-cell acute lymphoblastic leukemia · score 0.33
- Sezary's disease · score 0.33
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O95999-F1 | alphafold | PREDICTED | 69.49 | — |
Amino-acid sequence (233 residues)
MEPTAPSLTE EDLTEVKKDA LENLRVYLCE KIIAERHFDH LRAKKILSRE DTEEISCRTS SRKRAGKLLD YLQENPKGLD TLVESIRREK TQNFLIQKIT DEVLKLRNIK LEHLKGLKCS SCEPFPDGAT NNLSRSNSDE SNFSEKLRAS TVMYHPEGES STTPFFSTNS SLNLPVLEVG RTENTIFSST TLPRPGDPGA PPLPPDLQLE EEGTCANSSE MFLPLRSRTV SRQ
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