About NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 (NDUFB10) is a protein
from Homo sapiens identified by UniProt accession
O96000, 172 residues long.
MolForge cross-references it against 0 known binders and
235 disease associations.
Target properties
| Protein name | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 |
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| UniProt accession | O96000 |
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| Gene | NDUFB10 |
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| Organism | Homo sapiens |
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| Length | 172 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (235)
Diseases linked to this target (Open Targets).
- mitochondrial complex 1 deficiency, nuclear type 35 · score 0.67
- type 2 diabetes mellitus · score 0.61
- diabetes mellitus · score 0.60
- polycystic ovary syndrome · score 0.60
- type 1 diabetes mellitus · score 0.58
- gestational diabetes · score 0.58
- obesity · score 0.57
- prediabetes syndrome · score 0.56
- schizophrenia · score 0.55
- insulin resistance · score 0.55
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O96000-F1 | alphafold | PREDICTED | 90.75 | — |
Amino-acid sequence (172 residues)
MPDSWDKDVY PEPPRRTPVQ PNPIVYMMKA FDLIVDRPVT LVREFIERQH AKNRYYYYHR QYRRVPDITE CKEEDIMCMY EAEMQWKRDY KVDQEIINIM QDRLKACQQR EGQNYQQNCI KEVEQFTQVA KAYQDRYQDL GAYSSARKCL AKQRQRMLQE RKAAKEAAAA TS
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