About Heart- and neural crest derivatives-expressed protein 1
Heart- and neural crest derivatives-expressed protein 1 (HAND1) is a protein
from Homo sapiens identified by UniProt accession
O96004, 215 residues long.
MolForge cross-references it against 0 known binders and
85 disease associations.
Target properties
| Protein name | Heart- and neural crest derivatives-expressed protein 1 |
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| UniProt accession | O96004 |
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| Gene | HAND1 |
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| Organism | Homo sapiens |
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| Length | 215 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (85)
Diseases linked to this target (Open Targets).
- electrocardiography · score 0.39
- QRS duration · score 0.37
- QRS complex · score 0.33
- balding measurement · score 0.30
- QRS amplitude · score 0.30
- left ventricular structural measurement · score 0.29
- hair shape measurement · score 0.25
- hypoplastic left heart syndrome · score 0.19
- congenital heart disease · score 0.19
- chin morphology measurement · score 0.12
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O96004-F1 | alphafold | PREDICTED | 64.95 | — |
Amino-acid sequence (215 residues)
MNLVGSYAHH HHHHHPHPAH PMLHEPFLFG PASRCHQERP YFQSWLLSPA DAAPDFPAGG PPPAAAAAAT AYGPDARPGQ SPGRLEALGG RLGRRKGSGP KKERRRTESI NSAFAELREC IPNVPADTKL SKIKTLRLAT SYIAYLMDVL AKDAQSGDPE AFKAELKKAD GGRESKRKRE LQQHEGFPPA LGPVEKRIKG RTGWPQQVWA LELNQ
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